Rajeswari

Indian Medical Gazette – APRIL, I999

ALOES COMPOUND-Versatality in Gynaecological Practice

 Rajeswari, Kakarla

Prof of Obstetrics & Gynecology.

Deparrment of Obstetrics & Gynecology,

S . V Medical College, Tirupati, AP

 

Aloes Compound is an indigenous drug from ALARSIN Pharmaceuticals. The drug trial was conducted in Govt. Maternity Hospital, Tirupati. Seventy five patients were taken for study during the period or 1 995-1997 for a period or 2 years. The drug was administered mainly as a drug for infertility. However, in some adolescent  girls, in  whom  the hormone administration has limitations without full endocrine profile, the drug was administered to regularise the cycle. All the patients were studied after basic investigations. The results were encouraging both in fertility patients and adolescent girls.

 

Pharmacology
Aloes Indica 70mg
Myrrh 70mg
Manjista 35mg
Karia (Iron) Bhasma 30mg
Hurmal 35mg
Kamboji 30mg
Jeevanti 30mg

Each  component  of  drug  has  its  specific  action  like increasing the vascularity or the pelvic organs (Aloes indica) and   stimulation  or  pelvic  circulation .  Hence  useful  in hypomenorrheic  cycle.

Another component BALMYRRH which is haematinic, must have been working to improve the anaemic state or woman and thereby 1mproving the general well-being and in particular intrauterine environment.

Selection of  Patients

Seventy five patients were selected for our drug trial. Some of them were From Hospital practice and some from Consulting practice. All these patients underwent the basic investigations and hormonal estimations like TSH and prolactin estimation . In all the patient’s tubal block was excluded.

Seventy five patients were  divided  into  various  groups as per age, marital status, as per the complaints. diagnosis and therapeutic  evaluation  and  results (Tables  1 ,2,3 and  4).

TABLE I
Presentation of Age

Total No of cases :75

Age

 No of Cases

Percent

16-20 yrs

 15

20

21-25 yrs

 24

32

26-30 yrs

 30

40
31-35 yrs 6

8

 

TABLE 2
Marital Status

Unmarried

 Married

Total No of Cases
7(10%) 68(90%)

75

 

Table 3
Complaint- Wise

Complaint-wise

 No.of Cases Percent

Irregular Periods

 20

31
Andious to conceive

52

 Primary

 38 67
  Secondary

14

Primary Sterility

 38
Secondary 14

Menorrhagia 3

2

 

Table 4


Diagnosis
No.of Cases		 Drug Administered Duration of treatment
Results
Percent

Primary -Infertility

 38 Aloes Compound

3 months
1 tid

Secondary – Infertility

 14 “

“

Infertility

 52 “ “ 30

58
Irregular cycles 30 “ “ 9

45

Results

After analysing the data, the response found :

  1. Infertility cases …. 50%
  2. Irregular cycles …..45 %

Discussion

The drug trial was conducted mainly in infertile group and concomitantly the drug was also tried in irregular cycles in adolescent  group. The results were  encouraging.

Two cases of Hyperprolactinemia were also tried, both of them conceived.

Conclusion

The drug Aloes Compound represents a broad spectrum of activity. In infertile woman, it is working like a fertility agent. In the  adolescent  girls, in  whom  hormonal  preparations  have  limited  role,  Aloes  Compound  is  working  dramatically  by regularising the cycle (working like a ovulation induction drug).It is presumed that each component of drug could be working in certain individuals in certain conditions. Mainly working as fertility agent in infertility, ovulation induction drug in irregular cycles, enhancing the glycogen content in hypoglycogen uterus and so on.

Aloes Compound is an  indigenous  drug,  it  may  not withstand  for challenges  for  its  pharmacodynamics actions.

However, the drug is worth trying in :

  1. Adolescent girls.
  2. Obesity with Irregular Cycles.
  3. Infertile woman with low income group (who cannot afford sophisticated investigations and hormonal treatment).

The only side effect that is noticed is constipation (because of iron component). Hence, the drug can be taken for further research in the ground of good endocrinal  laboratory .

Acknowledgement

 My sincere thanks to ALARSIN Company who gave good encouragement by  providing  the drug  and  material  and  also my heartful thanks to Dr. P. Sarojin i Devi , MD, DGO ., Superintendent, Govt. Maternity Hospital , Tirupati , who has given pe1mission to take up the patients for trial as well as my profound  thanks to my all beloved  Postgraduates who helped in this drug trial.

References

  1. Jagadeswari. S. -Indian J. of Clinical Practice. Vol. No. 6 : PP. 47-48; Feb. 1996 (Clinical Trials of ALARSIN Products)
  2. Krishna Mukherjee. M .S. — Proceedings of 24t h AICOG. New Delhi, 1972 .
  3. Roshan R. Balsara –Indian Practitioner : 19 : 1 . 123- 125 : Jan. 1996.