MYRON – FOR TREATMENT OF SPECIFIC &
NON-SPECIFIC LEUCORRHOEA
By
D. S. KAMAT, M.D., D.G.O., Research Officer (I.C.M.R.)
DR. S. A. GUPTE, M.B.B.S., D.G.O., Asstt. Research Officer
DR. V. D. KAMAT, M.D., D.G.O., Research Officer, (I.C.M.R.)
DR. P. C. SANKHOLKAR, M.D., D.G.O., Professor
DEPARTMENT OF OBSTETRICS & GYNAECOLOGY,
B.J. MEDICAL COLLEGE & SASSOON GENERAL
HOSPITALS, PUNE-411 001
MYRON — FOR TREATMENT OF SPECIFIC & NON-SPECIFIC LEUCORRHOEA
Leucorrhoea is an everyday problem to the practicing gynaecologist. It occurs in a third of all gynaecological cases. Its causes may vary from increased physiological secretion to serious local and systemic disease. In susceptible women it is likely to create a sense of insecurity, depression and even fright. Good number of women are found to be suffering from either trichomonal or monilial vaginitis.
The present clinical trial with Myron was undertaken to study the efficacy, as it is said to remove the root cause of leucorrhoea.
MATERIAL & METHODS:-
74 consecutive cases of leucorrhoea attending the Sassoon General Hospitals, Poona during 1976 were studied. A thorough general and local examination was done. Vaginal smear was examined in all the cases. Where microscopical smear examination did not reveal any organism, smear culture was done. Repeat smear examination was done in all the cases after 2 weeks and after 4 weeks of Myron treatment, though culture was not repeated. Negative smear examination along with symptomatic relief was taken for the assessment of response to Myron. Beside this, routine blood examination and urine examination were done in all the cases.
MYRON:-
Myron is an Ayurvedic drug, contains processed ingredients of Myrrh, Guggul (Mukul), Shilajit and Bang, Abhrak and Kasis (Loha) Bhasmas.This combination is said to stimulate, tone up and regulate the functions of genito-urinary system. It has anti-inflammatory, anti-bacterial, antiseptic, disinfectant properties. It also stimulates phagocytosis and enhances the healing process.
Myron was given 2 tablets thrice a day for 2 weeks and then 2 tablets twice a day for 2 more weeks. Bangshil which is an urinary antiseptic and is said to detoxicate genito urinary system and raise the body resistance was also given for the first 2 weeks in a same dose with Myron in cases of Trichomonal infection.
AGE:-
The largest age group having leucorrhoea was of 21-25 years with 40.5%. Out of 74 cases 49 were married and 12 were unmarried. There were 13 cases of Primary Sterility.
(Table 1).
|
Age Group |
Married Unmarried Primary
sterility |
Total | % | ||
| 18-20 | 9 | 6 | 6 | 21 | 28.3 |
|
21-25 |
18 | 6 | 6 | 30 |
40.5 |
|
26-30 |
12 | — | — | 12 |
16.2 |
| 31-35 | 6 | — | — | 6 |
8.1 |
|
36-40 |
1 | — | 1 | 2 |
2.7 |
| 41-45 | 3 | — | — | 3 |
4.0 |
| Total | 49 | 12 | 13 | 74 |
99.8 |
SYMPTOMS:-
Backache was the main presenting symptom observed in 77% cases. Pruritus and burning micturation was noticed in 36.4% and 24.3% of cases respectively. The details of symptoms are given in Table II.
TABLE-II Symptoms
|
Symptoms |
No. | % |
| Backache | 57 | 77.0 |
| Pruritus | 27 | 36.4 |
| Burning Micturation | 18 | 24.3 |
| Menstrual disorder | 15 | 20.2 |
| Pain in Hypogastrium | 15 | 20.2 |
| Pusparunia | 12 | 16.2 |
NATURE OF VAGINAL DISCHARGE:
35.1% patients had cheesy discharge while 27% had frothy-green discharge (Table III)
TABLE-III
Nature of Vaginal Discharge
|
Type of Discharge |
No. | % |
| Mucoid | 10 |
13.5 |
| Creamy | 18 |
24.3 |
| Frothy-Green | 20 |
27.0 |
|
Cheesy |
26 |
35.1 |
| Total | 74 |
99.9 |
EXAMINATION OF SMEAR & CULTURE:
32(43.2%) patients had Monilial and 24(32.4%) had T. Vaginalis infection. In 8(10.8%) patients mixed infection of both Monilial and T. Vaginalis was detected. In 10(13.5%) patients no organism was detected and they were taken as non-specific leucorrhoea (Table IV).
TABLE-IV
Vaginal Smear
| Type | No. | % |
|
Monilial |
32 |
43.2 |
|
Trichomonal |
24 | 32.4 |
| Monilial + Trichomonal | 8 |
10.8 |
| Nonspecific | 10 |
13.5 |
| Total | 74 |
99.9 |
OTHER INVESTIGATIONS:-
Haemogram: Haemoglobin of these patients ranged from 7.4 gm% to 12 gm% with the mean of 9.2 gm% .
Urine Examination:- In 8 (33.3%) patients of T. Vaginalis infection motile Trichomonas were detected in microscopic examination of urine. A positive evidence of associated urinary infection was detected in 20 (27%) cases of leucorrhoea.
Erosion & cervicitis :- 12 (16.2%) patients had erosion of cervix and 10 (13.5%) had cervicitis. In 12 (16.2%) cases cauterization was done following treatment of Tricomoniasis and Monilial infection with Myron.
Other Drugs: 9 (12.1%) patients were actually treated with Tab. Matranidazol fortnight before the present treatment as they failed to respond to previous Matranidazol course.
Response to Myron Treatment: 68.7% cases of Monilial and 58.3% cases of Trichomonal infection had complete relief in 2 weeks of treatment with Myron and Myron + Bangshil respectively. 20% patients with nonspecific leucorrhoea had complete relief within 2 weeks. 6 out of 10 patients of these nonspecific leucorrhoea had chronic cervicitis and one had erosion.
59 (79.7%) had complete relief after Myron treatment after 4 weeks. After 4 weeks 15 (20.2%) patients failed to show the complete relief. In majority of cases with erosion and chronic cervicitis improvement was observed. Mild erosion and inflammation had disappeared but in 12 (16.2%) cases cauterization was needed to obtain the complete relief from leucorrhoea. The details of response to Myron are given in Table V.
TABLE-V
Response to Myron Treatment
|
Type
|
No. of cases
|
Complete relief 2 weeks |
Complete relief 4 weeks |
Total
|
No relief
|
|
Monilial |
32 |
22 (68.7%) |
6 (18.7%) |
28 (87.5%) |
4 (12.5%) |
|
Trichomona |
24 |
14 (58.3%) |
3 (12.5%) | 17 (70.8%) | 7 (29%) |
|
Mixed |
8 | 1 (12.5%) | 5 (62.5%) | 6 (75%) |
2 (25%) |
| Nonspecific | 10 | 2 (20%) | 6 (75%) | 2 (25%) | |
| Total | 74 | 39 (52.7%) | 20 (27%) | 59 (79.7%) |
15 (20.2%) |
SIDE EFFECTS:
No toxic or side effects were observed with Myron and Bangshil during the trial.
CONCLUSION AND SUMMARY:-
Overall response with Myron was 79.7% Complete relief from leucorrhoea in a maximum period of 4 weeks was observed. 20.2% cases failed to show a satisfactory response.
Cervix becomes healthy after Myron therapy in cases of mild erosion of cervix. In present situation many times specific drugs like Hamycin or Nystatine for Monilial infection are not available. Many times the culture facility is not available except in major centers. Considering all these obstacles routine therapy with Myron or Myron + Bangshil for Monilial or T. Vaginalis infection will be beneficial in majority of cases with low cost and without any side effects.
ACKNOWLEDGEMENT
We are thankful to Dean, B. J. Medical College for allowing to conduct this trial at Sassoon General Hospitals, Pune.
We are also thankful to Alarsin Pharmaceuticals, Bombay and Mr. Vilas Mohadikar from Alarsin for the supply of drug and necessary help for this clinical trial .
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