A TRIAL OF ALOES COMPOUND (INDIAN INDIGENOUS DRUG) IN CASE OF MENSTRUAL IRREGULARITY ASSOCIATED WITH STERILITY

by

KRISHNA MUKHERJEE^;, * M.S.

M. PANDE,^** M.S.

and

M. MUKHERJI,^*** M.D. F.R.C.O.G.

Irregular scanty menses is a fairly com­mon problem which a Gynaecologist meets with. Frequently these complaints are associated with primary or secondary sterility. About 1017,_o of sterile marriages no fault can be found in both the part­ners. (Brown 1964) In such cases simple advice some times does good. Some authors speak of "psychogenic sterility-­in which mental stress due to anxiety, worry or other emotional situations cause tubal spasm or even anovulation (hypothalamic amenorrhoea). In such the physician by establishing a sympathetic and understanding relationship with his patient may unconsciously assume the, role of psychotherapist, which may explain why many hitherto sterile women be­come pregnant during the course of in­vestigation." (Bos and Cleghorn 1958). Jeffcoate (1969^,) emphasises that "Psycho­logical factors may fail to supresas a stable ovarian and uterine -cycle completely and some times succeed only in reducing the amount of flow. The best example is pseudocyesis--which is frequently charac­terized by scanty period rather than amenorrhoea".

*Lecturer, Departrrient of Obst. & Gyn. **Resistrar Department of Obst. & Gyn., ***Professor and Head o f the Department a f Obstetrics and Gynaecology, M.L,N, Medical College, Allahabad,

Sterile woman becomes more appre­hensive, tense and mentally upset, which usually makes the menstrual cycle irre­gular or scanty. It is not clear whether the sterility is caused because of irregular or scanty <Periods or such menstrual disturbances are because of sterility.

Keeping the above facts in mind a trial of Aloes compound was made.

Material and Method

Cases of primary and secondary ste­rility with the history of irregular or scanty periods were collected from Kamla Nehru Memorial Hospital, Allahabad. The cases were grouped as follows:

l.	Primary sterility:	.	.	59 cases
	A. Oligomenorrhoea	.	.	20 cases
	B. Irregular periods	.	.	30 cases
2.	Secondary sterility	.	.	50 cases
	A. Oligomenorrhoea	.	.	15 cases
	B. Irregular periods	.	.	35 cases

A thorough history was taken specially regarding the menstrual pattern, dura­tion for which it has become irregular and fertility state of brothers and sisters. Proper, general systemic and local exa­mination was carried out. Premenstrual endometrial b:opsy, postmenstrual hyste­rosalpingography and semen analysis of every couple was done and the cases

where there was any organic cause far sterility or menstrual irregularity were excluded from the study. Selected cases were given "Aloes compound" for six consecutive cycles.

Pharmacology o f the Drug

The drug contains following^, ingredi­ents:

 

Showing the improvement in the menstrual cycle following treatment

	Types of Cases	Total numberImprovement within 3 Cycles of cases                                                      Number         Percentage
1.	Oligomenorrliaea
	(a) Primary sterility	20                                     17           85%
	(b) Secondary sterility	15                                     11           73.3%
2.	Irregular Periods
	(a) Primary sterility	30                                     26            86.6%
	(b) Secondary sterility	35                                      29           $2.$%
TABLE 2 Showing the conception rate
		Total number                                  Cases conceived
	Type at Cases	of cases                        Number            Percentage
l.	Primary sterility	50                                    8                          16%
2.	Secondary sterility	50                                    5                          10%

secondary sterility. It gives encouraging results in apprehensive and tense patients, who are over concerned for their niens­trual irregularity.

In the present study the conception rate is low, 16~/o and 10% in primary and secondary sterility respectively, in con­trast with the^, results: of Dr. Bulsara (1966) who reported pregnancy in 30 cases out of 45 cases of primary sterility and in 1 case out of 5 cases of secondary sterility. The low conception rate noted in the present series might be because of short follow up, (The maximum follow up period being 10 months). The rest of the cases are still under observation.

Acknowledgement

We  are     thankful   to     M/s.Alarsin Pharmaceuticals, Bombay-1 (B.R.) for supplying us with the tablets of Aloes

compound, by the kind co-operation of Mr. K. S. Mehrotra. (Supervisor) & Mr. Niraj Kumar (Medical Representative), Allahabad.

References

I .    Bos, C. and Cleghorn, R. A.: Fertil and steril. 9: 84, 1958. Quoted by Beowne, F. J. and Browne, J. C., McLure. "Post-graduate Obstetrics and Gynaecology" 3rd Ed. (1964) Butterworth & Co. (Publishers) Ltd.

Browne, F. J., Browne, J. C. and McLure: "Post-graduate Obstetrics and Gynaecology" 3rd Ed. (1964) Butterworth & Co. (Publishers) Ltd.

3. Bulsara Roshan R. (1966) sterility Associated with Irregular and scanty menstruation. Ind. Prac., 19: 1-123-5 Jan. 1966.
4. Jeffooate, T. N. A.: "Princtⁱples of Gynaecology" 3rd Ed. (1969) But­terworth & Co. (Publishers) Ltd.