R. COMPOUND V/S Oxyphenbutazone Aspirin
"in ACUTE SOFT TISSUE TRAUMA"
|
Tenderness over the
sprained and contused part disappeared within the 1st week in those
receiving |
"in ACUTE SOFT TISSUE
TRAUMA"
a Clinical Trial of R.Compound
by
Dr. L.V. Raghava Rao, M.S.,
Assistant Prof. in Orthopaedics
Kasturba Medical College, Manipal (Karnataka)
Paper at : Karnataka Orthopaedic Conference,
Manipal, Feb. 1976
Acute soft
tissue trauma in the form of sprains and contusions is of very common
occurrence. Numerous anti-inflammatories, analgesic drugs are available,
ranging from the basic aspirin to the phenylbutazone group, indomethacin and
ibuprofen, with their corresponding side effects. The Ayurvedic durg,
R. Compound (Alarsin) is said to be having anti-inflammatory and analgesic
activities comparable to hydrocortisone and butazolidine without any toxic
effects even on prolonged use.
The present
trial is designed to study the anti-inflammatory & analgesic properties of
R. Compound as compared to two other commonly used anti-inflammatory &
analgesic drugs, oxyphenbutazone and aspirin.
MATERIAL
AND METHODS
Thirty ambulatories otherwise healthy patients with acute soft tissue
trauma in the form of sprains, contusions, hemarthrosis knee and traumatic
synovitis were selected for this study, from the out-patient Department of
K.M.C. Hospital, Manipal. There were 18 men and 12 women. All these cases were
radiologically studied to eliminate any fractures. These patients were divided
into three groups of 10 each. Group I patients received R. Compound at a dose
of 1 tab/three times a day. Group II patients received oxyphenbutazone
(Tanderil - Geigy, Oxyrin - Themis) at a dose of 1 tab/ tds. Group III patients
received Aspirin at adose of 2 tab/tds. Side effects if any were noted. In all
these cases, treatment was instituted within 18 hours. (None of these cases
had any associated diseases).
CASES
ACCORDING TO DIAGNOSIS
Sprains around the ankle - 8
Sprains of wrist - 4
Hemarthrosis, knee - 3
Traumatic Synovitis - 4
Contusions - 11
-------------------
TOTAL 30
ADDITIONAL TREATMENT
All these cases were advised to take suitable physiotherapy in the form
of exercises and heat/cold as was indicated. In those cases with hemarthrosis
and traumatic synovitis of the knee, aspiration of the knee was done and a
compression bandage given.
OBSERVATIONS
The assessment was based on relief of symptoms against the number of days
of treatment.
|
Duration
of Treatment For Complete Relief |
|||
|
|
From Pain |
From Swelling |
From Tenderness |
|
Group I (R.Compound) |
5 days |
7 days |
7 days |
|
Group II (Oxphenbutazone) |
7 days |
7 days |
10 days |
|
Group III |
7 days |
10 days |
14 days |
Complete
relief from pain was noted within 3-7 days in patients receiving oxyphenbutazone
and aspirin; whereas the patients receiving R. Compound have noted complete
relief from pain within 3-5 days.
The swelling persisted particularly in
sprains and contusions after 1-week treatment with aspirin; whereas in
patients receiving oxyphenbutazone or R, Compound, the swelling disappeared
within 7 days.
Tenderness over
the sprained and contused part disappeared within the first week in those
receiving R. Compound. In the group receiving oxyphenbutazone, tenderness
lasted for 7 - 10 days and in the aspirin group, it persisted in some patients
even upto 14 days.
SIDE EFFECTS
No harmful side effects were noted in the
group treated with R, Compound. However, one patient complained about its
pungent smell. Both the other groups had shown some gastric irritation and
heart burn.
CONCLUSION
i)
The anti-infammatory and
analgesiaprop- erties of R. Compound (Alarsin) is comparable
to that of oxyphenbutazone and definitely superior to that of aspirin.
ii)
R. Compound is not
associated with any gastric irritation or any other side effects. Only
one patient in ten complained about its pungent smell.
iii)
R. Compound is
well-tolerated and economical.
ACKNOWLEDGEMENT
I thank Dr. V. Chacko Prof, of Orthopedics for
his valuable suggestions in preparing this paper, I am grateful to the Dean,
Kasturba Medical College, Manipal, for allowing me to conduct this trial and to
write this paper.
REFERENCES
1. H.VSardesai and S.S Deshpande: use of
R.Compound in Rheumatic arthritis: proceedings of the First Congress of the
S.E.A.P.A.L.A.R. Ed. ShantilalJ.Shah and members: Indian Rheumatism
Association, Bombay, P.P. 131-135.